The Official journal of the China Association of Rehabilitation of Disabled Persons and the 88th Hospital of PLA

Composite Impact Factor:

0. 948 (2015)

Total citation frequency: 3868 (2015)


ISSN 1005-8478

CN 37-1247/R

A meta-analysis on the effect of dexamethasone on pain, nausea and vomiting following primary total hip arthroplasty

Author : CAO Guo-rui, XU Hong, HUANG Qiang, CHEN Guo, LEI Yi-ting, PEI Fu-xing.     
Working unit : West China Hospital, Sichuan University, Chengdu 610041, China
Page : 2257-2261.
Key words : total hip arthroplasty, dexamethasone, pain, nausea, vomiting
Abstract: [Objective] To assess the effect of dexamethasone on pain, nausea and vomiting following primary total hip arthroplasty (THA) . [Methods] Literatures on the application of dexamethasone following primary THA were retrieved from databases, such as Pubmed, Web of Science, EMBASE, Cochrane Library, CNKI and VIP before March 2019. The related data collected were statistically analyzed using RevMan 5.3 software to compare the occurrence of pain, nausea and vomiting in the early stage after operation. [Results] A total of 8 high quality prospective clinical RCTs meeting the inclusion criteria were included into this study. As results of the meta-analysis, the dexamethasone significantly decreased the VAS score in 24 hours (MD=0.88, 95% CI : -1.19~-0.56, P<0.001) and in 48 hours (MD=-0.64, 95% CI: -1.15~-0.13, P=0.01) , as well as significantly reduced hospital stay (MD=-0.75, 95% CI: -0.96~-0.55, P<0.001) , and significantly declined the incidence of nausea and vomiting (OR=0.12, 95% CI: 0.07~0.21, P<0.001) after primary THA. [Conclusion] The application of dexamethasone effectively relieve pain, shorten hospital stay, as well as decline the incidence of nausea and vomiting after primary THA.
summary:
A meta-analysis on the effect of dexamethasone on pain, nausea and vomiting following primary total hip arthroplasty   
CAO Guo-rui, XU Hong, HUANG Qiang, CHEN Guo, LEI Yi-ting, PEI Fu-xing.
Orthop J Chin, 27(24):   2257-2261.