The Official journal of the China Association of Rehabilitation of Disabled Persons and the 88th Hospital of PLA

Composite Impact Factor:

0. 948 (2015)

Total citation frequency: 3868 (2015)


ISSN 1005-8478

CN 37-1247/R

Role of circRNA in intervertebral disc degeneration

Author : SUN Hong-zhi, SUN Zhong-yi, LIN Hao, WANG Ze-yu, WANG Hai-bin, TIAN Ji-wei.     
Working unit : Department of Orthopedics, The Affiliated Nanjing Jiangbei People's Hospital, Nantong University, Nanjing 210048, China
Page : 2262-2266.
Key words : intervertebral disc degenerative, circRNA, diagnostic marker, molecular target
Abstract: With the development of the social economy and the change of people's life styles, the incidence of intervertebral disc degeneration (IDD) in China is increasing year by year. An early research point of view is that the degeneration of the intervertebral disc is caused by the ageing of the elderly population. However, in recent years, the incidence of intervertebral disc degeneration has a younger trend. It is urgent to find effective molecular targets for the treatment of intervertebral disc degeneration. The circRNA is a kind of noncoding RNA, which widely exists in different species and human cells, and has high conservativeness and tissue specificity. This article reviews the research progress on the formation and function of circRNA and the role of circRNA in disc degeneration.
summary:
Role of circRNA in intervertebral disc degeneration   
SUN Hong-zhi, SUN Zhong-yi, LIN Hao, WANG Ze-yu, WANG Hai-bin, TIAN Ji-wei.
Orthop J Chin, 27(24):   2262-2266.