To evaluate the clinical outcome of 3 analgesic regimens after total knee arthroplasty （TKA） .
Consecutive 90 patients who underwent unilateral TKA were randomly divided into 3 groups with 30 patients in each group. Correspondingly, 3 perioperative analgesic regimens were given respectively, including “cocktail” joint cavity perfusion （the joint perfusion group） , multipoint periarticular injection point （the multipoint injection group） and femoral nerve block （the nerve block group） . Postoperatively the VAS, supplementary use of pethidine, adverse reactions and functional recovery were compared among 3 groups.
Although there were on significant differences
in VAS among the 3 groups at 6 h and 72 h postoperatively（P>0.05） ,
the patients in the nerve block group suffered from notable posterior
pain, associated with the highest VAS, which was statistically different
with the other two groups at 24 h after operation （P<0.05） .The
supplementary use of pethidine was not statistically different anomy the
3 groups, nevertheless adverse reactions occurred most frequently in
the nerve block group, where likewise was statistically different
compared to the other two groups （P<0.05） . In addition, the nerve
block group tended to make complaint of weakness of knee extension,
associated with significant differences in time to return active
straight leg raising and ambulation with the other two groups
（P<0.05） . At 3 months there were no statistical difference in HSS
anomy the 3 groups （P>0.05） .
The "cocktail" joint cavity perfusion for analgesia after total knee arthroplasty with advantages of easy handling, less adverse reaction, and facilitation to early rehabilitation, does achieves satisfactory clinical outcome.