The Official journal of the China Association of Rehabilitation of Disabled Persons and the 88th Hospital of PLA

Composite Impact Factor:

0. 948 (2015)

Total citation frequency: 3868 (2015)

ISSN 1005-8478

CN 37-1247/R

Comparison of three analgesic regimens after total knee arthroplasty

Author : ZHANG Yin, SHI Yong-an, YU Pan, et al.     
Working unit : Department of Anesthesia, The First Peoples Hospital of Nanyang, Nanyang 473010, China
Page : 1763-1766
Key words : total knee replacement, analgesia, joint cavity perfusion



To evaluate the clinical outcome of 3 analgesic regimens after total knee arthroplasty (TKA) .


Consecutive 90 patients who underwent unilateral TKA were randomly divided into 3 groups with 30 patients in each group. Correspondingly, 3 perioperative analgesic regimens were given respectively, including “cocktail” joint cavity perfusion (the joint perfusion group) , multipoint periarticular injection point (the multipoint injection group) and femoral nerve block (the nerve block group) . Postoperatively the VAS, supplementary use of pethidine, adverse reactions and functional recovery were compared among 3 groups.


Although there were on significant differences in VAS among the 3 groups at 6 h and 72 h postoperatively(P>0.05) , the patients in the nerve block group suffered from notable posterior pain, associated with the highest VAS, which was statistically different with the other two groups at 24 h after operation (P<0.05) .The supplementary use of pethidine was not statistically different anomy the 3 groups, nevertheless adverse reactions occurred most frequently in the nerve block group, where likewise was statistically different compared to the other two groups (P<0.05) . In addition, the nerve block group tended to make complaint of weakness of knee extension, associated with significant differences in time to return active straight leg raising and ambulation with the other two groups (P<0.05) . At 3 months there were no statistical difference in HSS anomy the 3 groups (P>0.05) .


The "cocktail" joint cavity perfusion for analgesia after total knee arthroplasty with advantages of easy handling, less adverse reaction, and facilitation to early rehabilitation, does achieves satisfactory clinical outcome.

Comparison of three analgesic regimens after total knee arthroplasty   
ZHANG Yin, SHI Yong-an, YU Pan, et al.
Orthop J Chin,2017,25(19):   1763-1766