The Official journal of the China Association of Rehabilitation of Disabled Persons and the 88th Hospital of PLA

Composite Impact Factor:

0. 948 (2015)

Total citation frequency: 3868 (2015)


ISSN 1005-8478

CN 37-1247/R

Efficacy and safety of oral pregabalin for analgesia after total knee arthroplasty

Author : XIE Xiao-wei, KANG Peng-de, SHENBin, et al.     
Working unit : Department of Orthopaedics, West China Hospital,Sichuan University, Chengdu, 610041,China
Page : 1978-1981
Key words : pregabalin， total knee arthroplasty， enhanced recovery after surgery， pain control

Abstract:

The aim of enhanced recovery after surgery （ERAS）is to reduce surgical stress and incidences of pain and

complications, enhance functional rehabilitation, and improve patients satisfaction by using approved efficient methods in peri⁃operative period. Better pain control is the basis of ERAS. Recent evidence suggests that α2-δ subunit calcium channel li⁃
gands, like pregabalin, may aid in providing effective postsurgical analgesia. They mitigate central sensitization by calming
down hyperexcited dorsal horn neurons. Therefore, application of pregabalin may be an effective method for reducing early post⁃operative pain and narcotic consumption.
summary:
Efficacy and safety of oral pregabalin for analgesia after total knee arthroplasty   
XIE Xiao-wei, KANG Peng-de, SHENBin, et al.
Orthop J Chin,2017,25(21):   1978-1981