The Official journal of the China Association of Rehabilitation of Disabled Persons and the 88th Hospital of PLA

Composite Impact Factor:

0. 948 (2015)

Total citation frequency: 3868 (2015)

ISSN 1005-8478

CN 37-1247/R

Recent studies on signaling pathway in distraction osteogenesis

Author : LIU Kai, ZHOU Nuo.     
Working unit : Department of Oral and Maxillofacial Surgery, College of Stomatology, Guangxi Medical University, Nanning 530021, China
Page : 230-233
Key words : distraction osteogenesis, signaling pathway, bone formation


Distraction osteogenesis (DO) is a kind of endogenous tissue engineering technique that can regenerate new bone by the bone callus healing mechanism. In recent years, as a large number of basic researches and clinical application of DO accumulated, this technique shows broad application prospect in the craniomaxillofacial and plastic surgery, such as  defect reconstruction after tumor resections and alveolus endosseous implant restoration. Study on signaling pathways in DO to explore the molecular mechanism are the key points to promote bone formation and mineralization in the DO area, and shorten the treatment cycle of patients with various diseases. Therefore, it is necessary to explore these signaling pathways in DO and mutual relation and regulation of cell mechanics signaling effect. This paper reviews the recent researches on the signaling pathways of DO.

Recent studies on signaling pathway in distraction osteogenesis   
LIU Kai, ZHOU Nuo.
Orthop J Chin,2018,26(3):   230-233