The Official journal of the China Association of Rehabilitation of Disabled Persons and the 88th Hospital of PLA

Composite Impact Factor:

0. 948 (2015)

Total citation frequency: 3868 (2015)


ISSN 1005-8478

CN 37-1247/R

Efficiency of18 F-fluorodeoxyglucose coincidence imaging combined with synovial fluid CRP in diagnosis of periprosthetic joint infection in knee

Author : WANG Wu-lian, ZHENG Shi -xiong, LIN Yu, XIAO Li -li, ZHANG Yi-yuan.     
Working unit : Department of Joint Surgery, Fuzhou Second Hospital, Xiamen University, Fujian 350007, China
Page : 1811-1815
Key words : periprosthetic joint infection (PJI) , bacterial culture, combined assay,18 F-fluorodeoxyglucose coincidence imaging, synovial CRP
  Abstract: [Objective] To investigate the efficiency of 18 F-fluorodeoxyglucose ( 18 F-FDG) coincidence imaging combined with synovial CRP (the combined assay) for diagnosis of periprosthetic joint infection (PJI) of the knee. [Methods] A retrospective study was done on 87 patients who were highly suspected as periprosthetic infection. The 18 F-FDG imaging and synovial CPR were taken before revision surgery, and then bacterial culture was conducted using the tissue samples obtained from 5 different periprosthetic parts during operation. If it was negative, the culture was extended to 2 weeks, and the final results were used as analytical criteria to evaluate the efficacy and significance of the preoperative assays. [Results] Among the 87 patients,73 patients got positive results of bacterial culture (the PJI group) , while the remaining 14 patients proved negative (the non PJI group) . The combined assay achieved sensitivity of 89.04%, specificity of 92.86%, and accuracy of 89.66%. By contrast, the mere 18 F-FDG imaging got sensitivity of 87.67%, specificity of 71.43%, and accuracy of 85.06%, whereas the synovial CPR only had sensitivity of 90.41%, specificity of 57.14%, and accuracy of 82.76%. The combined assay was statistically superior to the mere 18 F-FDG imaging and the synovial CPR only in specificity and accuracy for diagnosis of PJI (P<0.05) . [Conclusion] The 18 F-fluorodeoxyglucose coincidence imaging combined with synovial CRP achieves highly improved specificity and accuracy in diagnosis of periprosthetic joint infection of the knee.
summary:
Efficiency of18 F-fluorodeoxyglucose coincidence imaging combined with synovial fluid CRP in diagnosis of periprosthetic joint infection in knee   
WANG Wu-lian, ZHENG Shi -xiong, LIN Yu, XIAO Li -li, ZHANG Yi-yuan.
Orthop J Chin,2018,26(19):   1811-1815